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Page 1
Did you mean vh and brain (1,058 results)?
Discovery of XL01126: A Potent, Fast, Cooperative, Selective, Orally Bioavailable, and Blood-Brain Barrier Penetrant PROTAC Degrader of Leucine-Rich Repeat Kinase 2.
Liu X, Kalogeropulou AF, Domingos S, Makukhin N, Nirujogi RS, Singh F, Shpiro N, Saalfrank A, Sammler E, Ganley IG, Moreira R, Alessi DR, Ciulli A. Liu X, et al. J Am Chem Soc. 2022 Sep 21;144(37):16930-16952. doi: 10.1021/jacs.2c05499. Epub 2022 Aug 25. J Am Chem Soc. 2022. PMID: 36007011 Free PMC article.
Initial designs and screens of PROTACs based on ligands for E3 ligases von Hippel-Lindau (VHL), Cereblon (CRBN), and cellular inhibitor of apoptosis (cIAP) identified the best degraders containing thioether-conjugated VHL ligand VH101. ...XL01126 exhibits high cell …
Initial designs and screens of PROTACs based on ligands for E3 ligases von Hippel-Lindau (VHL), Cereblon (CRBN), and cellular inhibit …
Role of SOCS and VHL Proteins in Neuronal Differentiation and Development.
Kanno H, Matsumoto S, Yoshizumi T, Nakahara K, Kubo A, Murata H, Shuin T, U HS. Kanno H, et al. Int J Mol Sci. 2023 Feb 15;24(4):3880. doi: 10.3390/ijms24043880. Int J Mol Sci. 2023. PMID: 36835292 Free PMC article. Review.
SOCSs recruit Elongin C, Elongin B, Cullin5(Cul5), and Rbx2, whereas VHL recruits Elongin C, Elongin B, Cul2, and Rbx1. SOCSs form SBC-Cul5/E3 complexes, and VHL forms a VBC-Cul2/E3 complex. ...In addition, because SOCS and VHL promote nerve regeneration, the …
SOCSs recruit Elongin C, Elongin B, Cullin5(Cul5), and Rbx2, whereas VHL recruits Elongin C, Elongin B, Cul2, and Rbx1. SOCSs form SB …
A novel small-molecule PROTAC selectively promotes tau clearance to improve cognitive functions in Alzheimer-like models.
Wang W, Zhou Q, Jiang T, Li S, Ye J, Zheng J, Wang X, Liu Y, Deng M, Ke D, Wang Q, Wang Y, Wang JZ. Wang W, et al. Theranostics. 2021 Mar 11;11(11):5279-5295. doi: 10.7150/thno.55680. eCollection 2021. Theranostics. 2021. PMID: 33859747 Free PMC article.
Methods: A novel small-molecule PROTAC, named as C004019 with a molecular mass of 1,035.29 dalton, was designed to simultaneously recruite tau and E3-ligase (Vhl) and thus to selectively enhance ubiquitination and proteolysis of tau proteins. ...Most importantly, both sing …
Methods: A novel small-molecule PROTAC, named as C004019 with a molecular mass of 1,035.29 dalton, was designed to simultaneously recruite t …
Hemangioblastomas and Other Vascular Origating Tumors of Brain or Spinal Cord.
Vetrano IG, Gioppo A, Faragò G, Pinzi V, Pollo B, Broggi M, Schiariti M, Ferroli P, Acerbi F. Vetrano IG, et al. Adv Exp Med Biol. 2023;1405:377-403. doi: 10.1007/978-3-031-23705-8_14. Adv Exp Med Biol. 2023. PMID: 37452946 Review.
Although most of the HBs are sporadic (57-75%), they represent a particular component of von Hippel-Lindau disease (VHL), an autosomal dominant syndrome with high penetrance, due to a germline pathogenic mutation in the VHL gene, which is a tumor suppressor with chr …
Although most of the HBs are sporadic (57-75%), they represent a particular component of von Hippel-Lindau disease (VHL), an autosoma …
Rb1/Rbl1/Vhl loss induces mouse subretinal angiomatous proliferation and hemangioblastoma.
Wei R, Ren X, Kong H, Lv Z, Chen Y, Tang Y, Wang Y, Xiao L, Yu T, Hacibekiroglu S, Liang C, Nagy A, Bremner R, Chen D. Wei R, et al. JCI Insight. 2019 Nov 14;4(22):e127889. doi: 10.1172/jci.insight.127889. JCI Insight. 2019. PMID: 31613797 Free PMC article.
Here we show that retinoblastoma tumor suppressor (Rb1) constrains expression of Hif target genes in the Vhl-/- retina. Deleting Rb1 induced extensive retinal neovascularization and autophagic ablation of photoreceptors in the Vhl-/- retina. ...Most stromal cells in …
Here we show that retinoblastoma tumor suppressor (Rb1) constrains expression of Hif target genes in the Vhl-/- retina. Deleting Rb1 …
Von Hippel-Lindau Syndrome.
van Leeuwaarde RS, Ahmad S, van Nesselrooij B, Zandee W, Giles RH. van Leeuwaarde RS, et al. 2000 May 17 [updated 2024 Feb 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. 2000 May 17 [updated 2024 Feb 29]. In: Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993–2024. PMID: 20301636 Free Books & Documents. Review.
CLINICAL CHARACTERISTICS: Von Hippel-Lindau syndrome (VHL) is characterized by hemangioblastomas of the brain, spinal cord, and retina; renal cysts and clear cell renal cell carcinoma; pheochromocytoma and paraganglioma; pancreatic cysts and neuroendocrine tumors; e …
CLINICAL CHARACTERISTICS: Von Hippel-Lindau syndrome (VHL) is characterized by hemangioblastomas of the brain, spinal cord, an …
Brain and/or Spinal Cord Tumors Accompanied with Other Diseases or Syndromes.
Capitanio JF, Mortini P. Capitanio JF, et al. Adv Exp Med Biol. 2023;1405:645-672. doi: 10.1007/978-3-031-23705-8_25. Adv Exp Med Biol. 2023. PMID: 37452957
Several medical conditions that interest both the brain and the spinal cord have been described throughout the history of medicine. ...The most common CNS syndromes that will be discussed in this chapter include neurofibromatosis (NF) types 1 and 2, von Hippel-Lindau (V …
Several medical conditions that interest both the brain and the spinal cord have been described throughout the history of medicine. . …
Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in Cancer with VHL Loss.
Liu X, Simon JM, Xie H, Hu L, Wang J, Zurlo G, Fan C, Ptacek TS, Herring L, Tan X, Li M, Baldwin AS, Kim WY, Wu T, Kirschner MW, Gong K, Zhang Q. Liu X, et al. Mol Cell. 2020 Mar 19;77(6):1294-1306.e5. doi: 10.1016/j.molcel.2020.01.009. Epub 2020 Feb 4. Mol Cell. 2020. PMID: 32023483 Free PMC article.
von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs). It is important to identify additional therapeutic targets in ccRCC downstream of VHL loss besides hypoxia-inducible factor 2alpha (HIF2alpha). By performing a genom …
von Hippel-Lindau (VHL) is a critical tumor suppressor in clear cell renal cell carcinomas (ccRCCs). It is important to identify addi …
Neurological applications of belzutifan in von Hippel-Lindau disease.
Zhang Y, Nguyen CC, Zhang NT, Fink NS, John JD, Venkatesh OG, Roe JD, Hoffman SC, Lesniak MS, Wolinsky JP, Horbinski C, Szymaniak BM, Buerki RA, Sosman JA, Shenoy NK, Lukas RV. Zhang Y, et al. Neuro Oncol. 2023 May 4;25(5):827-838. doi: 10.1093/neuonc/noac234. Neuro Oncol. 2023. PMID: 36215167 Free PMC article.
Von Hippel-Lindau (VHL) disease is a tumor predisposition syndrome caused by mutations in the VHL gene that presents with visceral neoplasms and growths, including clear cell renal cell carcinoma, and central nervous system manifestations, such as hemangioblastomas …
Von Hippel-Lindau (VHL) disease is a tumor predisposition syndrome caused by mutations in the VHL gene that presents with visc …
Central nervous system manifestations in VHL: genetics, pathology and clinical phenotypic features.
Gläsker S. Gläsker S. Fam Cancer. 2005;4(1):37-42. doi: 10.1007/s10689-004-5347-6. Fam Cancer. 2005. PMID: 15883708 Review.
This review focuses on CNS hemangioblastomas in von Hippel-Lindau (VHL) disease. The pathogenesis of these lesions remains unclear to date; however, biallelic inactivation of the VHL tumor suppressor gene is thought to be an important step. ...Furthermore, cases of …
This review focuses on CNS hemangioblastomas in von Hippel-Lindau (VHL) disease. The pathogenesis of these lesions remains unclear to …
322 results